In a world increasingly shaped by fluid concepts of gender, the Christian church is called to speak with both clarity and compassion. This article explores gender dysphoria from a biblical and theological perspective, offering a faithful response grounded in God’s creation of humanity as male and female. Drawing from Scripture, natural law, and pastoral experience, it provides insight into how Christians can understand and care for those struggling with gender identity while holding fast to the truth of God’s Word and the hope of the Gospel.